One year in circulation – an exciting journey for ADMET & DMPK
نویسندگان
چکیده
It is now almost a year since ADMET & DMPK launched. The current issue will be the final one for 2013. We are happy to report that it has been a very exciting year for the journal. In particular, we have published a range of articles, such as book reviews, original scientific papers, perspectives, opinions and mini reviews covering different areas of interest to the journal. This reflects the diversity of the type of articles that enables the exchange of knowledge and shared learning. We would like to take this opportunity to offer thanks for all the help and hard work from our editorial team for supporting the journal.
منابع مشابه
An in silico evaluation of the ADMET profile of the StreptomeDB database
BACKGROUND Computer-aided drug design (CADD) often involves virtual screening (VS) of large compound datasets and the availability of such is vital for drug discovery protocols. This paper presents an assessment of the "drug-likeness" and pharmacokinetic profile of > 2,400 compounds of natural origin, currently available in the recently published StreptomeDB database. METHODS The evaluation o...
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The goal of this paper is to develop a Decision Support System (DSS) as a journey planner in complex and large multimodal urban network called Rahyar. Rahyar attempts to identify the most desirable itinerary among all feasible alternatives. The desirability of an itinerary is measured by a disutility function, which is defined as a weighted sum of some criteria. The weight...
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Myotonic dystrophy 1 (DM1) is caused by a CTG expansion in the 3'-unstranslated region of the DMPK gene, which encodes a serine/threonine protein kinase. One of the common clinical features of DM1 patients is insulin resistance, which has been associated with a pathogenic effect of the repeat expansions. Here we show that DMPK itself is a positive modulator of insulin action. DMPK-deficient (dm...
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The choroid plexus maintains the homeostasis of critical molecules in the brain by regulating their transport between the blood and cerebrospinal fluid (CSF). The current study was designed to investigate the potential role of the blood-CSF barrier (BCSFB) in α-synuclein (a-Syn) transport in the brain as affected by exposure to manganese (Mn), the toxic metal implicated in Parkinsonian disorder...
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Introduction: There is a strong correlation between muscle weakness and the mobility children with cerebral palsy. For this reason, the focus of the intervention programs has been changed to to resistance exercises. The purpose of this study was effect of group resistance exercise with exciting music on spasticity, muscle strength and walking ability for children with cerebral palsy. Methods: T...
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